Differentiate the function with respect to x.

Let $y=\cos x \cdot \cos 2 x \cdot \cos 3 x$

Taking logarithm on both the sides, we obtain

$\log y=\log (\cos x \cdot \cos 2 x \cdot \cos 3 x)$

$\Rightarrow \log y=\log (\cos x)+\log (\cos 2 x)+\log (\cos 3 x)$

Differentiating both sides with respect to x, we obtain

$\frac{1}{y} \frac{d y}{d x}=\frac{1}{\cos x} \cdot \frac{d}{d x}(\cos x)+\frac{1}{\cos 2 x} \cdot \frac{d}{d x}(\cos 2 x)+\frac{1}{\cos 3 x} \cdot \frac{d}{d x}(\cos 3 x)$

$\Rightarrow \frac{d y}{d x}=y\left[-\frac{\sin x}{\cos x}-\frac{\sin 2 x}{\cos 2 x} \cdot \frac{d}{d x}(2 x)-\frac{\sin 3 x}{\cos 3 x} \cdot \frac{d}{d x}(3 x)\right]$

$\therefore \frac{d y}{d x}=-\cos x \cdot \cos 2 x \cdot \cos 3 x[\tan x+2 \tan 2 x+3 \tan 3 x]$