Besides better aeration and mixing properties,

The shake flask method is used for a small-scale production of biotechnological products in a laboratory. On the other hand, stirred tank bioreactors are used for a large-scale production of biotechnology products.

Stirred tank bioreactors have several advantages over shake flasks:

(1) Small volumes of culture can be taken out from the reactor for sampling or testing.

(2) It has a foam breaker for regulating the foam.

(3) It has a control system that regulates the temperature and pH.